Author Archives: morkovina
NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats. M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov
Abstract: We have evaluated the efficiency of a metabonomic approach to metabolic phenotyping and detection of early metabolic changes under a toxic influence. For this purpose, a metabolic profiling of rat liver was performed with 1H NMR spectroscopy. Rat tissues …
Role of intestinal mucin-2 in the effectiveness of the treatment of Helicobacter spp. infection in laboratory mice. E. A. Litvinova, M. D. Belyaev, A. V. Prokhortchouk, V. S. Korostina, E. B. Prokhortchouk, E. N. Kozhevnikova
Abstract: Abnormal synthesis of the main intestinal proteoglycan mucin-2 is typical of ulcerative colitis and Crohn’s disease in humans. Those morphological changes of the mucus layer affect the diversity of the intestinal microflora. Antibiotics may be ineffective or even dangerous …
Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy. K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev
Abstract: At present, there is no animal model for smallpox that reflects the weakened immune system in people and can therefore help assess the prophylactic (highly preventive) efficiency of antiviral drugs. To fill in the gap, we have explored the …
A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus. G. V. Kochneva, A. A. Grazhdantseva, G. F. Sivolobova, A. V. Tkacheva, A. N. Shvalov, A. Yu. Unusova, E. I. Ryabchikova, S. V. Netesov
Abstract: Human carcinoma A431 cells were subcutaneously injected into nude mice at points remote from each other. One of the two xenografts developed afterwards was used for treatment with a recombinant vaccinia virus, while another served as an artificial metastasis. …
Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice. N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov
Abstract: Ortho-aminoazotoluene (OAT) is a potent hepatocarcinogen for most strains of mice. It has previously been shown that OAT application activates the aryl hydrocarbon receptor (Ahr) and the constitutive androstane receptor (Car) in the mouse liver. Both of these receptors …
The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model. G. A. Maksimova, M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov
Abstract: The validity of experimental models of pathologies is one of the key challenges in translational medicine. Cholangiocarcinoma, or bile duct cancer, ranks second among oncological diseases of the liver. There is a strong association between bile duct cancer and …
In vivo MRI visualization of growth and morphology in the orthotopic xenotrasplantation U87 glioblastoma mouse SCID model. E. L. Zavjalov, I. A. Razumov, L. A. Gerlinskaya, A. V. Romashchenko
Abstract: Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer with the average lifespan of patients about 9–12 months. The study of tumor formation and the evaluation of new therapies for GBM require accurate and reproducible …
Stress and arterial hypertension: ISIAH rat strain. Ye. V. Antonov, Yu. V. Alexandrovich, A. A. Seryapina, L. O. Klimov, A. L. Markel
Abstract: The main views of the issue of stress and hypertension are briefly reviewed. It is well known that stress is one of the major risk factors for cardiovascular disease development. Increase in blood pressure is a typical manifestation of …
Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development. N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova
Abstract: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. It produces atrophic changes in the brain, which cause dementia. The incidence of AD is increasing with increasing life expectancy and gradual aging of the population in developed countries. There are …
Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles. D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin
Abstract: Air pollution by particulate matter (PM) has been associated with cardiopulmonary morbidity and mortality in many recent epidemiological studies. It has been shown that transition metal compounds, well- known toxic components of PM, are able to induce hypothermia following …
